Description

1,2,3,4-Tetrahydro-3-Isoquinolinecarboxylic Acid T-Butyl Ester is a protected amino acid derivative that serves as a critical chiral building block in advanced organic synthesis. Its value lies in providing a versatile scaffold for constructing complex nitrogen-containing heterocycles, which are central to modern pharmaceutical discovery. This high-purity intermediate is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of isoquinoline-based drug candidates, including potential central nervous system (CNS) agents and enzyme inhibitors.
• Peptidomimetics Research: Used in the design and construction of peptidomimetic compounds, where the tetrahydroisoquinoline core mimics peptide turn structures.
• Agrochemical Synthesis: Serves as a precursor in the development of novel herbicides and pesticides with specific biological activity.
• Asymmetric Catalysis: Employed as a substrate or ligand precursor in asymmetric synthesis to induce chirality in target molecules.
• Chemical Biology Probes: Utilized in the creation of molecular probes for studying biological pathways and protein interactions.
• Academic & Contract Research: A valuable reagent for methodological development in academic laboratories and contract research organizations (CROs).

Basic Information

Product Name	1,2,3,4-Tetrahydro-3-Isoquinolinecarboxylic Acid T-Butyl Ester
CAS No.	82716-91-4
Molecular Formula	C14H19NO2
Molecular Weight	233.31 g/mol
Synonyms	3-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline; tert-Butyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate; 1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid 1,1-dimethylethyl ester; Boc-Tic-OH; Boc-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic Acid; 3-Boc-1,2,3,4-tetrahydroisoquinoline; Tic(Boc)-OH
EINECS	Contact for details

Quality Control

Our 1,2,3,4-Tetrahydro-3-Isoquinolinecarboxylic Acid T-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials such as strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.