Description

3-Isoquinolinecarboxylic Acid, 1,2,3,4-Tetrahydro-, 1,1-Dimethylethyl Ester, Hydrochloride, (S)- is a high-purity, single-enantiomer chiral building block essential for advanced pharmaceutical synthesis. This compound is valued for its role as a key intermediate in the development of active pharmaceutical ingredients (APIs) and complex organic molecules. It is primarily required by research institutions and manufacturers in the pharmaceutical, agrochemical, and fine chemical sectors for process development and scale-up.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and cardiovascular therapeutic areas.
• Asymmetric Synthesis: Used as a starting material or reagent in stereoselective reactions to construct complex molecular architectures with high enantiomeric purity.
• Agrochemical Research: Serves as a building block for developing new, optically active crop protection agents and pesticides.
• Catalyst and Ligand Development: Potential precursor for novel chiral catalysts or ligands used in homogeneous catalysis.
• Academic & Contract Research: Employed in medicinal chemistry programs and process chemistry research within academic and contract research organizations (CROs).
• Fine Chemical Production: Integral to the multi-step synthesis of specialty chemicals and other high-value, low-volume products.

Basic Information

Product Name	3-Isoquinolinecarboxylic Acid, 1,2,3,4-Tetrahydro-, 1,1-Dimethylethyl Ester, Hydrochloride, (S)-
CAS No.	82586-60-5
Molecular Formula	C15H20ClNO2
Molecular Weight	281.78 g/mol
Synonyms	(S)-1,2,3,4-Tetrahydro-3-isoquinolinecarboxylic acid tert-butyl ester hydrochloride; (S)-1-tert-Butyl 1,2,3,4-tetrahydroisoquinoline-3-carboxylate hydrochloride; (S)-Tic-OtBu·HCl; tert-Butyl (S)-1,2,3,4-tetrahydroisoquinoline-3-carboxylate hydrochloride; (S)-3-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride; (S)-1,2,3,4-Tetrahydroisoquinoline-3-carboxylic acid tert-butyl ester hydrochloride; (S)-N-Boc-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride
EINECS	Contact for details

Quality Control

Our 3-Isoquinolinecarboxylic Acid, 1,2,3,4-Tetrahydro-, 1,1-Dimethylethyl Ester, Hydrochloride, (S)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Enantiomeric Excess)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.