Description

2,4-Dichloro-5-Cyanothiazole is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. Its molecular structure, featuring reactive chloro and cyano substituents, makes it a critical precursor for constructing complex molecules with tailored properties. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of various drug candidates, particularly those containing thiazole cores, such as kinase inhibitors and antimicrobial agents.
• Agrochemical Active Ingredient Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, leveraging its halogenated thiazole structure.
• Material Science Research: Serves as a building block for creating functional polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing groups.
• Dye and Pigment Manufacturing: Employed in the synthesis of specialized heterocyclic dyes and colorants.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, or Buchwald-Hartwig amination to introduce the thiazole moiety into more complex systems.
• Nucleophilic Substitution Chemistry: The chlorine atoms are readily displaced by various nucleophiles (amines, alkoxides) to create a diverse library of 2,4-disubstituted thiazole derivatives.

Basic Information

Product Name	2,4-Dichloro-5-Cyanothiazole
CAS No.	82554-18-5
Molecular Formula	C4Cl2N2S
Molecular Weight	178.99 g/mol
Synonyms	5-Cyano-2,4-dichlorothiazole; 2,4-Dichloro-5-thiazolecarbonitrile; 2,4-Dichlorothiazole-5-carbonitrile; Thiazole, 2,4-dichloro-5-cyano-; 5-Thiazolecarbonitrile, 2,4-dichloro-; 82554-18-5; 2,4-Dichloro-5-cyanothiazole
EINECS	Contact for details

Quality Control

Every batch of 2,4-Dichloro-5-Cyanothiazole is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.