Description

Acetamide, n-[(1,1-Dimethylethyl)dimethylsilyl]-n-methyl- is a specialized organosilicon-protected acetamide derivative, serving as a valuable synthetic intermediate and protecting group reagent in advanced organic synthesis. Its core value lies in providing a robust, silyl-based protective strategy for amide functionalities, enabling selective transformations in complex molecule construction. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity building blocks for developing new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly for protecting sensitive amide groups during multi-step reactions.
• Peptide & Protein Research: Used in the modification and protection of amino acid side chains in peptide synthesis and bioconjugation chemistry.
• Agrochemical Synthesis: Intermediate in the development of new herbicides, fungicides, and insecticides requiring specialized silicon-containing motifs.
• Organometallic Chemistry: Precursor or ligand in catalytic systems and the preparation of silicon-functionalized metal complexes.
• Material Science: Used in the surface modification of silica-based materials and the synthesis of silicon-containing polymers.
• Academic & R&D Laboratories: A versatile reagent for methodological development in organic synthesis and new reaction discovery.

Basic Information

Product Name	Acetamide, n-[(1,1-Dimethylethyl)dimethylsilyl]-n-methyl-
CAS No.	82112-20-7
Molecular Formula	C9H21NOSi
Molecular Weight	187.36 g/mol
Synonyms	N-(tert-Butyldimethylsilyl)-N-methylacetamide; N-Methyl-N-(tert-butyldimethylsilyl)acetamide; N-(t-Butyldimethylsilyl)-N-methylacetamide; N-Methylacetamide N-(tert-butyldimethylsilyl) derivative; Acetamide, N-methyl-N-[(1,1-dimethylethyl)dimethylsilyl]-; TBDMS-N-methylacetamide; N-Methyl-N-(TBDMS)acetamide; tert-Butyldimethylsilyl N-methylacetamide
EINECS	Contact for details

Quality Control

Our Acetamide, n-[(1,1-Dimethylethyl)dimethylsilyl]-n-methyl- is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and process-scale applications. We provide comprehensive analytical data, including HPLC, GC, and NMR analysis, to verify identity and purity. Certificates of Analysis (COA) are available for every batch upon request, detailing all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.