Description

Z-Ligustilide (CAS NO 81944-09-4) is a principal bioactive phthalide derivative and a key marker compound found in traditional Chinese herbs such as *Angelica sinensis* (Danggui) and *Ligusticum chuanxiong*. This compound is highly valued for its significant pharmacological activities, including anti-inflammatory, neuroprotective, and vasodilatory effects. It is a critical standard and active ingredient for the pharmaceutical, nutraceutical, and research sectors, where precise quality and reliable supply are paramount for product development and quality control.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified reference material (CRM) for the quality control and assay of herbal extracts and finished products.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a key building block in the synthesis of novel therapeutic agents targeting inflammation and cardiovascular diseases.
• Nutraceutical & Dietary Supplements: Incorporated into formulations for women's health and circulatory support, capitalizing on its traditional use and modern research.
• Biomedical Research: Essential tool for in vitro and in vivo studies investigating mechanisms of action related to its anti-inflammatory and neuroprotective properties.
• Cosmeceuticals: Used in advanced skincare products for its potential anti-inflammatory and circulation-enhancing benefits.
• Analytical Chemistry: Employed as a calibration standard in HPLC, LC-MS, and GC-MS methods for the quantification of ligustilide in complex matrices.

Basic Information

Product Name	Z-Ligustilide
CAS No.	81944-09-4
Molecular Formula	C12H14O2
Molecular Weight	190.24 g/mol
Synonyms	(Z)-3-Butylidene-4,5-dihydrophthalide; (Z)-3-Butylidenephthalide; Ligustilide; Senkyunolide (common name); 3-Butylidene-1(3H)-isobenzofuranone; (Z)-Ligustilide; Phthalide, 3-butylidene-; Danggui lactone
EINECS	Contact for details

Quality Control

Our Z-Ligustilide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and residual solvent analysis. We provide Certificates of Analysis (COA) with detailed chromatograms and full traceability. The product meets stringent standards suitable for research and development use, with higher purity grades available to meet pharmaceutical reference standard requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and degradation. For long-term storage, keep the sealed container in a freezer at -20°C. Allow the container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Colorless to pale yellow oily liquid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.