Description

Lasiocarpine n-Oxide is a pyrrolizidine alkaloid derivative, a compound of significant interest in biochemical and pharmacological research. Its value lies in its role as a key reference standard and intermediate for studying the metabolism, toxicity, and potential biological activities of pyrrolizidine alkaloids. This high-purity compound is essential for researchers and quality control laboratories in the pharmaceutical, toxicology, and natural product sectors who require reliable analytical standards.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the identification and quantification of pyrrolizidine alkaloids and their metabolites in drug substances and herbal products.
• Toxicological Research: Serves as a critical metabolite in studies investigating the hepatotoxic and carcinogenic mechanisms of pyrrolizidine alkaloids.
• Analytical Method Development: Employed for calibrating instruments and validating analytical methods such as HPLC, LC-MS, and GC-MS in food safety and phytochemical analysis.
• Biochemical Studies: Utilized as a substrate or inhibitor in enzymatic studies to understand the bioactivation pathways of natural toxins.
• Quality Control (QC) Testing: Acts as an impurity standard in the QC testing of pharmaceuticals and dietary supplements to ensure compliance with safety regulations regarding pyrrolizidine alkaloid content.

Basic Information

Product Name	Lasiocarpine n-Oxide
CAS No.	127-30-0
Molecular Formula	C21H33NO7
Molecular Weight	411.49 g/mol
Synonyms	Lasiocarpine N-Oxide; Lasiocarpine Oxide; 7-(2-Methylbutyryloxy)-9-[(2S,3R,4S,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)oxolan-2-yl]oxy-8,10-dihydroxy-6,8a-dimethyl-5,6,7,8,8a,9-hexahydroindolizine 5-oxide; (1R,7aR)-1-[(2S,3R,4S,5S)-3,4,5-Trihydroxy-2-(hydroxymethyl)oxolan-2-yl]oxy-6,7,7a,8-tetrahydro-5H-pyrrolizin-1-ium-7-yl (2S)-2-methylbutanoate oxide
EINECS	Contact for details

Quality Control

Our Lasiocarpine n-Oxide is produced and tested under a rigorous quality management system. Each batch is analyzed to meet high-purity standards suitable for research and analytical applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and related substances is provided to ensure traceability and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.