Description

Aristolochic Acid-I, Methyl Ester is a specific, high-purity derivative of the naturally occurring nephrotoxin, aristolochic acid I. This compound is of significant value in biochemical and pharmacological research, particularly for its role as a reference standard and a tool compound. It is primarily needed by research institutions, pharmaceutical development laboratories, and analytical service providers engaged in toxicology studies, metabolic pathway investigation, and the development of detection methods for aristolochic acid contaminants.

Application

• Analytical Reference Standard: Serves as a critical certified standard for the qualitative and quantitative analysis (e.g., HPLC, LC-MS) of aristolochic acids in herbal products, pharmaceuticals, and biological samples.
• Biochemical Research: Used as a tool compound to study the mechanisms of aristolochic acid-induced nephropathy (AAN) and carcinogenesis in in vitro and in vivo models.
• Metabolite Studies: Employed in research to identify and characterize the metabolic pathways and derivatives of aristolochic acids.
• Toxicology & Safety Assessment: Essential for calibrating equipment and validating methods in laboratories focused on the safety screening of botanicals and traditional medicines.
• Method Development & Validation: A key component in developing, optimizing, and validating new analytical techniques for the detection of these regulated contaminants.
• Quality Control Laboratories: Used by QC labs in the pharmaceutical and nutraceutical industries to ensure raw materials and finished products are free from aristolochic acid contamination.

Basic Information

Product Name	Aristolochic Acid-I, Methyl Ester
CAS No.	1169-60-4
Molecular Formula	C18H13NO7
Molecular Weight	355.30 g/mol
Synonyms	8-Methoxy-6-nitrophenanthro[3,4-d][1,3]dioxole-5-carboxylic acid, methyl ester; Aristolochic acid I methyl ester; Aristolochic acid A methyl ester; Methyl aristolochate I; Tardolyt; Isoaristolochic acid I methyl ester
EINECS	Contact for details

Quality Control

Our Aristolochic Acid-I, Methyl Ester is produced and handled under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, MS), to ensure it meets the high standards required for research and analytical applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 95.0% (Area %)
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.