Description

1H-Indole, 4-(3-Piperidinyl)-, (R)- is a chiral indole derivative of significant interest in advanced organic synthesis and pharmaceutical research. This compound, identified by CAS NO 81887-48-1, serves as a sophisticated building block for the development of novel bioactive molecules. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and biotechnology sectors for creating targeted therapeutic agents, particularly in neuroscience and oncology.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of potential drug candidates targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and high-throughput screening libraries to explore new pharmacophores.
• Asymmetric Synthesis: Employed as a starting material or intermediate in catalytic asymmetric reactions to construct complex, enantiomerically pure molecules.
• Biochemical Tool Compound: Utilized in vitro and in vivo to study biological pathways and receptor interactions related to indole alkaloid signaling.
• Process Chemistry & Scale-up: Serves as a critical intermediate for the pilot-scale and commercial-scale manufacturing of active pharmaceutical ingredients (APIs).
• Contract Research & Development (CRO/CMO): Supplied to organizations specializing in custom synthesis and development services for the life sciences industry.

Basic Information

Product Name	1H-Indole, 4-(3-Piperidinyl)-, (R)-
CAS No.	81887-48-1
Molecular Formula	C13H16N2
Molecular Weight	200.28 g/mol
Synonyms	(R)-4-(3-Piperidinyl)-1H-indole; (R)-4-(Piperidin-3-yl)-1H-indole; (R)-3-(1H-Indol-4-yl)piperidine; (R)-4-(3-Piperidyl)indole; (R)-Norharman derivative; (R)-4-(3-Piperidinyl)indole; (R)-4-Piperidin-3-yl-1H-indole; (R)-γ-Carboline analogue
EINECS	Contact for details

Quality Control

Every batch of (R)-4-(3-Piperidinyl)-1H-indole is produced and tested under strict quality management systems to ensure consistency and reliability for research and development purposes. We provide comprehensive analytical data, including chiral purity verification by HPLC. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is supplied with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.