Description

Trimethylsilyl Cyanide-13C,15N is a stable isotopic-labeled reagent of significant value in advanced analytical and synthetic chemistry. Its core value proposition lies in providing a dual-labeled (13C and 15N) silyl cyanide source, enabling precise tracking and quantification in complex molecular systems. This compound is essential for researchers and process developers in pharmaceutical R&D, agrochemical synthesis, and metabolic studies who require high-fidelity isotopic tracers for mechanism elucidation and analytical method development.

Application

• Pharmaceutical Research & Development: As a key labeled synthon for the preparation of isotopically labeled active pharmaceutical ingredients (APIs), metabolites, and internal standards for bioanalytical assays (LC-MS/MS).
• Metabolic Pathway Tracing: Used in the synthesis of probes to study drug metabolism, pharmacokinetics, and biochemical pathways using advanced mass spectrometry techniques.
• NMR Spectroscopy: Serves as a precursor for introducing 13C and 15N labels into target molecules, enhancing signal detection and simplifying spectral interpretation in structural analysis.
• Agrochemical Science: Employed in the synthesis of labeled pesticide analogs and degradation products for environmental fate studies and residue analysis.
• Organic Synthesis: Functions as a versatile labeled cyanide anion equivalent in nucleophilic addition and cyanation reactions under mild conditions.
• Forensic & Doping Control Analysis: Used to create certified reference materials and labeled standards for accurate quantification in forensic toxicology and anti-doping programs.

Basic Information

Product Name	Trimethylsilyl Cyanide-13C,15N
CAS No.	81797-53-7
Molecular Formula	13C15NSi(CH3)3 or C313CH915NSi
Molecular Weight	~100.17 g/mol (labeled)
Synonyms	((Trimethylsilyl)carbon-13C,nitrogen-15N)cyanide; Cyanotrimethylsilane-13C,15N; TMSCN-13C,15N; Trimethylsilyl-13C,15N-cyanide; (Trimethylsilyl)-13C,15N Cyanide; NSC 112093-13C,15N; TMS-CN-13C,15N; Silicon cyanide trimethyl-13C,15N
EINECS	Contact for details

Quality Control

Our Trimethylsilyl Cyanide-13C,15N is manufactured under strict quality systems to ensure the highest isotopic and chemical purity for sensitive research applications. Each batch is characterized by advanced analytical techniques including NMR, GC-MS, and IR spectroscopy to confirm isotopic enrichment, chemical identity, and purity. Certificates of Analysis (COA) detailing isotopic purity (atom % 13C and 15N), chemical assay, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (argon or nitrogen) to maintain stability. Keep away from strong acids, strong bases, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC)	≥ 98.0%
Isotopic Purity (13C)	≥ 99 atom %
Isotopic Purity (15N)	≥ 99 atom %
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.