Description

Bambuterol Hydrochloride is a selective beta2-adrenergic receptor agonist prodrug, primarily metabolized to the active form terbutaline. This compound is of significant commercial interest due to its role as a key pharmaceutical intermediate in the synthesis of long-acting bronchodilator medications. It is essential for manufacturers in the global pharmaceutical industry, particularly those developing treatments for respiratory conditions such as asthma and chronic obstructive pulmonary disease (COPD).

Application

• Pharmaceutical Active Ingredient (API): Primary use as a prodrug intermediate in the manufacture of prescription bronchodilator medications.
• Respiratory Drug Formulation: Critical component in the development and production of tablets and other dosage forms for asthma management.
• Research & Development: Used in preclinical and clinical research for studying beta2-adrenergic agonist pathways and developing new therapeutic entities.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory testing in pharmaceutical laboratories.
• Chemical Synthesis: Employed as a specialized building block in organic synthesis for creating novel derivatives with potential pharmacological activity.

Basic Information

Product Name	Bambuterol Hydrochloride
CAS No.	81732-46-9
Molecular Formula	C18H29N3O5 • HCl
Molecular Weight	403.90 g/mol
Synonyms	Bambuterol HCl; KWD 2019; (RS)-5-[2-(tert-Butylamino)-1-hydroxyethyl]-1,3-phenylene bis(dimethylcarbamate) hydrochloride; 1,3-Bis[(dimethylamino)carbonyl]-5-[2-[(1,1-dimethylethyl)amino]-1-hydroxyethyl]benzene hydrochloride; Terbutaline bisdimethylcarbamate hydrochloride
EINECS	Contact for details

Quality Control

Our Bambuterol Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and impurity profiles. We support compliance with cGMP, ICH Q7 guidelines, and relevant pharmacopeial standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.