Description

5-Chloroindole-3-Acetonitrile is a versatile halogenated indole derivative that serves as a critical synthetic intermediate in advanced organic chemistry. Its value lies in the reactive nitrile and chloro-substituted indole scaffold, enabling the construction of complex heterocyclic systems and active pharmaceutical ingredients (APIs). This high-purity building block is essential for research and development chemists in the pharmaceutical, agrochemical, and advanced material sectors seeking to develop novel compounds with targeted biological or functional properties.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel indole-based drug candidates, including potential serotonin receptor modulators and kinase inhibitors.
• Agrochemical Research: Building block for developing new generation plant growth regulators or herbicides with specific mode-of-action.
• Organic Synthesis: Versatile starting material for constructing complex heterocycles via reactions at the nitrile and chloro functional groups.
• Biochemical Probe Development: Used in research to create molecular probes for studying enzyme function and cellular signaling pathways.
• Material Science: Potential monomer or precursor for specialty polymers and advanced organic electronic materials.

Basic Information

Product Name	5-Chloroindole-3-Acetonitrile
CAS No.	81630-83-3
Molecular Formula	C10H7ClN2
Molecular Weight	190.63 g/mol
Synonyms	5-Chloro-1H-indole-3-acetonitrile; (5-Chloro-1H-indol-3-yl)acetonitrile; 3-(Cyanomethyl)-5-chloroindole; 5-Chloroindolyl-3-acetonitrile; 5-Chloro-3-indoleacetonitrile; 81630-83-3; 5-Cl-IAN
EINECS	Contact for details

Quality Control

Our 5-Chloroindole-3-Acetonitrile is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or production specifications. Custom purity grades and analytical packages are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.