Description

17Alpha-Estradiol-2,4-D2 is a deuterated analog of the endogenous estrogen, 17α-estradiol, specifically labeled at the 2 and 4 positions of the aromatic ring. This compound is of significant value as a stable isotope-labeled internal standard in analytical chemistry, providing enhanced accuracy and reliability in quantitative mass spectrometry. It is primarily required by research institutions, pharmaceutical development laboratories, and contract research organizations (CROs) engaged in bioanalytical method development, pharmacokinetic studies, and metabolic research.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of endogenous 17α-estradiol and related metabolites in complex biological matrices like plasma, serum, and tissue homogenates.
• Biomedical Research: Used in tracer studies to investigate the pharmacokinetics, metabolic pathways, and bioavailability of estradiol analogs.
• Pharmaceutical Development: Supports Good Laboratory Practice (GLP) compliant bioanalysis during pre-clinical and clinical trials for hormone-related therapies.
• Endocrinology Studies: Aids in the sensitive and specific measurement of steroid hormones in endocrinological research and diagnostic assay development.
• Doping Control Analysis: Employed in sports anti-doping laboratories for the definitive identification and quantification of prohibited anabolic agents.
• Metabolomics: Serves as a stable isotope reference in high-throughput screening for steroid hormone profiling.

Basic Information

Product Name	17Alpha-Estradiol-2,4-D2
CAS No.	81586-94-9
Molecular Formula	C18H22D2O2
Molecular Weight	274.40 g/mol
Synonyms	Estra-1,3,5(10)-triene-3,17α-diol-2,4-D2; 17α-Estradiol-2,4-D2; [2,4-D2]-17α-Estradiol; 1,3,5(10)-Estratrien-3,17α-diol-2,4-d2; Deuterated 17α-Estradiol; 17α-Hydroxyestra-1,3,5(10)-trien-3-ol-2,4-D2
EINECS	Contact for details

Quality Control

Our 17Alpha-Estradiol-2,4-D2 is manufactured under strict quality systems to ensure the high chemical purity and isotopic enrichment required for sensitive analytical applications. Each batch is characterized by advanced spectroscopic and chromatographic techniques, including NMR, HPLC, and mass spectrometry, to confirm identity, chemical purity, and deuterium incorporation. Certificates of Analysis (COA) detailing batch-specific results are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.