Description

(4As,8As)-Octahydroisoquinolin-4A(2H)-Ol is a high-purity, advanced pharmaceutical intermediate with a defined stereochemistry. This compound matters for its role as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in neurological and cardiovascular therapeutic areas. It is primarily needed by pharmaceutical R&D teams, process chemists, and manufacturers engaged in the development of novel, stereochemically pure drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex alkaloid-based active pharmaceutical ingredients (APIs).
• Neurological Drug Research: Used in the development of compounds targeting neurotransmitter pathways and neurological disorders.
• Cardiovascular Drug Development: Serves as a precursor in the synthesis of molecules for cardiovascular disease treatment.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or building block in stereoselective chemical reactions.
• Organic Chemistry Research: A valuable compound for academic and industrial research in heterocyclic and medicinal chemistry.
• Process Chemistry Optimization: Employed in scaling up synthetic routes from laboratory to pilot and commercial production.

Basic Information

Product Name	(4As,8As)-Octahydroisoquinolin-4A(2H)-Ol
CAS No.	81562-77-8
Molecular Formula	C9H17NO
Molecular Weight	155.24 g/mol
Synonyms	(4aR,8aS)-Octahydroisoquinolin-4a(2H)-ol; (4aR,8aS)-Octahydro-2H-isoquinolin-4a-ol; (4aR,8aS)-4a-Hydroxydecahydroisoquinoline; (4aR,8aS)-4a-Hydroxy-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline; cis-Octahydroisoquinolin-4a-ol; (4aR,8aS)-Octahydro-2H-isoquinolin-4a-ol; (4aR,8aS)-4a-Hydroxydecahydroisoquinoline
EINECS	Contact for details

Quality Control

Our (4As,8As)-Octahydroisoquinolin-4A(2H)-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (4aR,8aS)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.