Description

3H-Indole, 2,3,3-Trimethyl-5-(Trifluoromethyl)- is a specialized indole derivative characterized by its trifluoromethyl substitution, a structural feature that imparts unique electronic and steric properties. This compound serves as a critical advanced pharmaceutical intermediate (API intermediate) and a versatile building block in modern synthetic chemistry. It is primarily utilized by R&D and production teams in the pharmaceutical, agrochemical, and material science sectors for developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Organic Light-Emitting Diode (OLED) Materials: Acts as a core structure or dopant in the creation of electron-transporting or emissive layers for display and lighting technologies.
• Ligand and Catalyst Development: Employed in organometallic chemistry to create novel ligands for catalysis, leveraging the indole scaffold's coordinating properties.
• Fluorescent Probe and Dye Synthesis: Serves as a building block for designing sensitive chemical sensors and specialized dyes used in bioimaging and diagnostics.
• Academic and Industrial R&D: A valuable reagent for methodological studies in organic synthesis, including fluorination chemistry and heterocycle functionalization.

Basic Information

Product Name	3H-Indole, 2,3,3-Trimethyl-5-(Trifluoromethyl)-
CAS No.	81558-22-7
Molecular Formula	C12H12F3N
Molecular Weight	227.23 g/mol
Synonyms	2,3,3-Trimethyl-5-(trifluoromethyl)-3H-indole; 5-(Trifluoromethyl)-2,3,3-trimethylindolenine; 2,3,3-Trimethyl-5-trifluoromethylindolenine; 5-Trifluoromethyl-2,3,3-trimethyl-3H-indole; 3H-Indole, 2,3,3-trimethyl-5-(trifluoromethyl)-; Indolenine, 5-(trifluoromethyl)-2,3,3-trimethyl-
EINECS	Contact for details

Quality Control

Every batch of 3H-Indole, 2,3,3-Trimethyl-5-(Trifluoromethyl)- is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for research and commercial synthesis. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from strong alkalis and fluorides. For long-term storage, consider inert gas purging to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.