Description

1-Methyl-4-Tosylimidazole-5-Thiol is a specialized heterocyclic building block featuring a tosyl-protected imidazole core with a reactive thiol group. This compound matters as a versatile intermediate for synthesizing complex molecules, particularly in pharmaceutical research and advanced material science. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly those targeting enzymes and receptors where the imidazole-thiol motif is pharmacologically active.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides, leveraging its heterocyclic structure for bioactivity.
• Ligand and Catalyst Precursor: Serves as a precursor for creating specialized ligands in coordination chemistry and catalysis, useful in asymmetric synthesis and polymerization processes.
• Material Science Research: Employed in the development of advanced polymers, conductive materials, or metal-organic frameworks (MOFs) due to its functional groups that can facilitate cross-linking or metal binding.
• Bioconjugation Chemistry: The reactive thiol group can be utilized for site-specific modification of proteins, peptides, or other biomolecules in biochemical research.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis houses serving the life sciences sector, enabling the production of bespoke compounds for client projects.

Basic Information

Product Name	1-Methyl-4-Tosylimidazole-5-Thiol
CAS No.	81291-85-2
Molecular Formula	C11H12N2O2S2
Molecular Weight	268.35 g/mol
Synonyms	4-Methyl-1-tosyl-1H-imidazole-5-thiol; 1-Methyl-4-(p-toluenesulfonyl)imidazole-5-thiol; 1H-Imidazole-5-thiol, 1-methyl-4-[(4-methylphenyl)sulfonyl]-; 5-Mercapto-1-methyl-4-tosylimidazole; 1-Methyl-4-tosyl-1H-imidazole-5-thiol; 4-Tosyl-1-methylimidazole-5-thiol
EINECS	Contact for details

Quality Control

Our 1-Methyl-4-Tosylimidazole-5-Thiol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.