Description

(Trifluoromethyl)Trimethylsilane is a versatile organosilicon reagent featuring a reactive trifluoromethyl group. This compound is valued for its ability to efficiently introduce the trifluoromethyl moiety into organic molecules, a key modification in modern synthetic chemistry. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for the development of novel compounds with enhanced properties.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs) containing the CF3 group, which improves metabolic stability and lipophilicity.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity.
• Fluorinated Material Precursor: Serves as a monomer or modifying agent in the creation of specialty polymers, coatings, and liquid crystals with unique chemical resistance and surface properties.
• Nucleophilic Trifluoromethylation: Acts as a nucleophilic CF3- source under mild conditions for reactions with various electrophiles like carbonyl compounds and alkyl halides.
• Organic Synthesis Reagent: Employed in cross-coupling reactions and as a reagent for the direct trifluoromethylation of aromatics and heteroaromatics.
• Laboratory Research: Essential for medicinal chemistry and discovery chemistry programs focused on structure-activity relationship (SAR) studies.

Basic Information

Item	Detail
Product Name	(Trifluoromethyl)Trimethylsilane
CAS No.	81290-20-2
Molecular Formula	C4H9F3Si
Molecular Weight	142.20 g/mol
Synonyms	Trimethyl(trifluoromethyl)silane; Ruppert-Prakash Reagent; (Trifluoromethyl)trimethylsilicon; TMSCF3; CF3TMS; Trifluoromethyltrimethylsilane; Silicon, trimethyl(trifluoromethyl)-; 1,1,1-Trifluoro-N,N,N-trimethylsilanamine
EINECS	Contact for details

Quality Control

Our (Trifluoromethyl)Trimethylsilane is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality system is designed to meet the stringent requirements of pharmaceutical and advanced R&D applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and oxidizing agents. Due to its highly volatile nature, ensure containers are kept tightly sealed and at temperatures recommended on the specific material safety data sheet (MSDS).

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.