Description

2-(p-(2H-Indazol-2-Yl)Phenyl)-2-Methylpropionic Acid is a high-purity, non-steroidal anti-inflammatory drug (NSAID) intermediate with the CAS number 81265-70-5. This compound is a critical building block in the synthesis of advanced pharmaceutical active ingredients, offering a precise chemical structure for targeted therapeutic development. It is essential for research institutions and pharmaceutical manufacturers engaged in the development of novel anti-inflammatory and analgesic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of proprietary NSAIDs and other therapeutic molecules.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and new drug discovery programs.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a core scaffold in multi-step synthesis routes for final API production.
• Biochemical Research: Employed as a tool compound for studying cyclooxygenase (COX) enzyme inhibition pathways.
• Contract Manufacturing: Supplied to CDMOs for the production of clinical trial materials and commercial drug substances.

Basic Information

Product Name	2-(p-(2H-Indazol-2-Yl)Phenyl)-2-Methylpropionic Acid
CAS No.	81265-70-5
Molecular Formula	C18H16N2O2
Molecular Weight	292.33 g/mol
Synonyms	2-[4-(2H-Indazol-2-yl)phenyl]-2-methylpropanoic acid; 2-Methyl-2-[4-(2H-indazol-2-yl)phenyl]propanoic acid; 2-(4-(1H-Indazol-2-yl)phenyl)-2-methylpropanoic acid; Lornoxicam Impurity; Lornoxicam Related Compound; Oxicam Derivative; COX-2 Inhibitor Intermediate
EINECS	Contact for details

Quality Control

Our 2-(p-(2H-Indazol-2-Yl)Phenyl)-2-Methylpropionic Acid is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your regulatory and R&D requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and organic solvents. The container must be kept tightly closed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.