Description

n-(2,2,2-Trifluoroethoxycarbonyl)Imidazole is a specialized reagent primarily used as a versatile building block and activating agent in organic synthesis. Its value lies in its ability to introduce the trifluoroethoxycarbonyl protecting group, which is crucial for the synthesis of complex molecules, particularly in pharmaceutical research and development. This compound is essential for chemists and manufacturers in the pharmaceutical, agrochemical, and advanced material science sectors who require high-purity intermediates for peptide synthesis and the development of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Key reagent in the synthesis of novel drug candidates and active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Used as an activating agent for the introduction of the trifluoroethoxycarbonyl (Troc) protecting group in solid-phase and solution-phase peptide synthesis.
• Agrochemical Synthesis: Building block for creating advanced herbicides, fungicides, and insecticides with enhanced properties.
• Material Science: Intermediate in the production of specialty polymers and fluorinated materials.
• Bioconjugation: Employed in modifying biomolecules for research and diagnostic applications.
• Custom Synthesis: Serves as a starting material for contract research organizations (CROs) and CDMOs developing proprietary compounds.

Basic Information

Product Name	n-(2,2,2-Trifluoroethoxycarbonyl)Imidazole
CAS No.	81265-32-9
Molecular Formula	C7H7F3N2O2
Molecular Weight	208.14 g/mol
Synonyms	1-[(2,2,2-Trifluoroethoxy)carbonyl]imidazole; 2,2,2-Trifluoroethyl Imidazole-1-carboxylate; Troc-Imidazole; 1H-Imidazole-1-carboxylic Acid 2,2,2-Trifluoroethyl Ester; 1-Carboxyimidazole 2,2,2-Trifluoroethyl Ester; N-(Trifluoroethoxycarbonyl)imidazole; Imidazole-1-carboxylic Acid Trifluoroethyl Ester
EINECS	Contact for details

Quality Control

Our n-(2,2,2-Trifluoroethoxycarbonyl)Imidazole is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality system is designed to meet the rigorous standards demanded by pharmaceutical and research customers globally.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure containers are sealed immediately after use to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.