Description

(1S,4S)-2-Oxa-5-Azabicyclo[2.2.1]Heptan-3-One is a high-purity, chiral bicyclic lactam compound that serves as a critical advanced pharmaceutical intermediate (API) and a versatile building block in asymmetric synthesis. Its rigid, fused-ring structure provides a valuable scaffold for constructing complex molecules with precise stereochemistry, enabling the development of novel active pharmaceutical ingredients. This compound is essential for research and production in pharmaceutical chemistry, particularly for medicinal chemists and process development scientists working on central nervous system (CNS) agents, enzyme inhibitors, and other therapeutic classes.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of complex drug molecules, particularly those targeting neurological pathways.
• Asymmetric Synthesis: Utilized as a building block for constructing enantiomerically pure compounds in medicinal chemistry and total synthesis projects.
• Protease Inhibitor Development: Serves as a core structural motif in the research and development of novel protease inhibitors.
• Chemical Biology & Probe Design: Used in the creation of molecular probes to study enzyme function and biological pathways.
• Process Chemistry & Scale-up: Employed in the development and optimization of scalable synthetic routes for GMP manufacturing.
• Academic & Industrial R&D: A valuable reagent for research laboratories focused on heterocyclic chemistry and new synthetic methodologies.

Basic Information

Product Name	(1S,4S)-2-Oxa-5-Azabicyclo[2.2.1]Heptan-3-One
CAS No.	81025-84-5
Molecular Formula	C6H7NO2
Molecular Weight	125.13 g/mol
Synonyms	(1S,4S)-2-Oxa-5-azabicyclo[2.2.1]heptan-3-one; (1S,4S)-(-)-2-Oxa-5-azabicyclo[2.2.1]heptan-3-one; (1S,4S)-5-Aza-2-oxabicyclo[2.2.1]heptan-3-one; (-)-2-Oxa-5-azabicyclo[2.2.1]heptan-3-one; (1S,4S)-Lactam Oxa-Aza Bicyclic Compound; Bicyclic γ-Lactam; Chiral Oxazolidinone Analog
EINECS	Contact for details

Quality Control

Our (1S,4S)-2-Oxa-5-Azabicyclo[2.2.1]Heptan-3-One is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and production. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to guarantee traceability and compliance with your internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.