Description

(1R,2S)-(-)-Ephedrine Nitrate is the nitrate salt of the stereoisomerically pure (-)-ephedrine alkaloid. This high-purity chiral intermediate is critical for ensuring the precise pharmacological activity and regulatory compliance of final pharmaceutical products. It is primarily utilized by manufacturers in the pharmaceutical, fine chemical, and research sectors requiring a specific enantiomer for synthesis.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of specific enantiomerically pure active pharmaceutical ingredients (APIs).
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control testing of ephedrine-based products.
• Chemical Synthesis: Employed in asymmetric synthesis and research chemistry where the (1R,2S) configuration is required.
• Decongestant & Bronchodilator Precursor: Serves as a starting material for the production of specific stereoisomers used in respiratory medications.

Basic Information

Product Name	(1R,2S)-(-)-Ephedrine Nitrate
CAS No.	81012-98-8
Molecular Formula	C10H15NO·HNO3 / C10H16N2O4
Molecular Weight	228.25 g/mol
Synonyms	(-)-Ephedrine Nitrate; (1R,2S)-(-)-Ephedrine Mononitrate; l-Ephedrine Nitrate; Ephedrine (1R,2S) nitrate salt; 1R,2S-(-)-Ephedrine nitrate; Erythro-(-)-ephedrine nitrate; [R-(R*,S*)]-α-[1-(Methylamino)ethyl]benzenemethanol nitrate
EINECS	Contact for details

Quality Control

Our (1R,2S)-(-)-Ephedrine Nitrate is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets stringent specifications for pharmaceutical-grade intermediates. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.5%
Chiral Purity (HPLC)	≥ 99.0% (1R,2S)-(-)-isomer
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.