Description

4-((3-Hydroxy-1H-Indazol-1-Yl)Phenyl)-2-Methylacetic Acid is a high-purity, non-steroidal anti-inflammatory drug (NSAID) intermediate of significant pharmaceutical importance. This compound is a key synthetic precursor in the development of novel COX-2 inhibitors and other therapeutic agents targeting inflammation and pain. It is primarily required by pharmaceutical R&D laboratories, fine chemical manufacturers, and contract research organizations (CROs) engaged in advanced drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: Critical building block for the synthesis of next-generation non-steroidal anti-inflammatory drugs (NSAIDs) and COX-2 inhibitors.
• Drug Discovery & Development: Used in medicinal chemistry research for creating novel anti-inflammatory and analgesic candidate molecules.
• Biochemical Research: Serves as a reference standard and a tool compound in studies of cyclooxygenase enzyme pathways and mechanisms of action.
• Fine Chemical Synthesis: Employed in multi-step organic syntheses to introduce the indazole-acetic acid pharmacophore into more complex molecular architectures.
• Process Chemistry & Scale-Up: Utilized in the development and optimization of commercial-scale manufacturing routes for active pharmaceutical ingredients (APIs).

Basic Information

Product Name	4-((3-Hydroxy-1H-Indazol-1-Yl)Phenyl)-2-Methylacetic Acid
CAS No.	80934-60-7
Molecular Formula	C₁₆H₁₄N₂O₃
Molecular Weight	282.30 g/mol
Synonyms	4-(3-Hydroxy-1H-indazol-1-yl)phenylacetic acid; 4-(3-Hydroxyindazol-1-yl)phenylacetic acid; 2-[4-(3-Hydroxy-1H-indazol-1-yl)phenyl]acetic acid; 4-(3-Hydroxy-1H-indazol-1-yl)benzeneacetic acid; 1-[4-(Carboxymethyl)phenyl]-1H-indazol-3-ol; 4-(3-Hydroxyindazol-1-yl)benzeneacetic acid; 80934-60-7 (CAS Registry)
EINECS	Contact for details

Quality Control

Our 4-((3-Hydroxy-1H-Indazol-1-Yl)Phenyl)-2-Methylacetic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical research. We provide comprehensive analytical documentation, including Certificates of Analysis (COA) with detailed HPLC chromatograms and impurity profiles. Our quality commitment aligns with ICH Q7 guidelines for active pharmaceutical ingredients (APIs) and intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). The product is compatible with strong acids and organic solvents but should be stored separately from strong bases and oxidizing agents. Keep the container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.