Description

Octahydroindole-2-Carboxylicacid(2S,3As,7As) is a high-purity, stereochemically defined bicyclic proline derivative, serving as a critical chiral building block in advanced organic synthesis. Its rigid, constrained structure is essential for inducing specific conformational properties in target molecules, directly impacting their biological activity and stability. This compound is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing peptide-based therapeutics, enzyme inhibitors, and other bioactive compounds where precise stereochemistry is non-negotiable.

Application

• Pharmaceutical Intermediates: A key chiral synthon for the synthesis of peptidomimetics and protease inhibitors.
• Peptide Chemistry: Used to incorporate a constrained proline analogue into peptide chains to enhance metabolic stability and modulate receptor binding.
• Drug Discovery: Serves as a scaffold in medicinal chemistry for creating libraries of compounds targeting neurological and cardiovascular diseases.
• Asymmetric Catalysis: Potential use as a precursor for chiral ligands or organocatalysts.
• Biochemical Research: Employed in studying protein folding and enzyme-substrate interactions due to its conformational rigidity.
• Agrochemical Synthesis: Intermediate for developing chiral active ingredients with improved efficacy and environmental profile.

Basic Information

Product Name	Octahydroindole-2-Carboxylicacid(2S,3As,7As)
CAS No.	80875-98-1
Molecular Formula	C9H15NO2
Molecular Weight	169.22 g/mol
Synonyms	(2S,3aS,7aS)-Octahydro-1H-indole-2-carboxylic acid; (2S,3aS,7aS)-2-Carboxyhexahydro-1H-indole; cis-Hexahydro-1H-indole-2-carboxylic acid (stereoisomer); (2S,3aS,7aS)-Perhydroindole-2-carboxylic acid; L-Octahydroindole-2-carboxylic acid; Conformationally constrained proline analogue; Bicyclic proline derivative
EINECS	Contact for details

Quality Control

We supply Octahydroindole-2-Carboxylicacid(2S,3As,7As) with a standard purity of ≥98% (HPLC), meeting the stringent requirements of pharmaceutical R&D. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing chiral purity, chemical purity, and residual solvent levels are available upon request. We adhere to a cGMP-compliant quality management system to ensure batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment. For long-term storage, consider using an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.