Description

4-Aminophenylboronic Acid Hydrochloride is a bifunctional organoboron compound that serves as a critical building block in modern synthetic chemistry. Its value lies in the combination of a reactive boronic acid group and a protected aniline moiety, enabling its use in cross-coupling reactions and as a precursor for more complex molecular architectures. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science sectors, particularly in the development of active pharmaceutical ingredients (APIs) and functional organic materials.

Application

• Pharmaceutical Intermediate: Key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing biaryl compounds found in drug candidates.
• API Synthesis: Used in the construction of complex molecules for oncology, CNS, and antiviral therapeutic areas.
• Agrochemical Research: Building block for creating novel herbicides, fungicides, and plant growth regulators.
• Material Science: Monomer or linker for synthesizing organic polymers, covalent organic frameworks (COFs), and advanced functional materials.
• Chemical Biology: Tool compound for bioconjugation and the development of boronic acid-based sensors and probes.
• Academic & R&D: Versatile reagent for methodological development in organic synthesis and catalysis research.

Basic Information

Product Name	4-Aminophenylboronic Acid Hydrochloride
CAS No.	80460-73-7
Molecular Formula	C6H9BClNO2
Molecular Weight	173.41 g/mol
Synonyms	(4-Aminophenyl)boronic acid hydrochloride; 4-Aminobenzeneboronic acid HCl; p-Aminophenylboronic acid hydrochloride; B-(4-Aminophenyl)boronic acid hydrochloride; 4-Boronoaniline hydrochloride; 4-ABPA HCl; 80460-73-7; Boronic acid, B-(4-aminophenyl)-, hydrochloride
EINECS	Contact for details

Quality Control

Our 4-Aminophenylboronic Acid Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high chemical purity and consistent performance in demanding synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or in a controlled environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.