Description

3-Iodo-1-(Phenylsulfonyl)-1H-Indole is a versatile and highly functionalized indole derivative, serving as a critical synthetic intermediate in advanced organic chemistry. Its unique structure, featuring both an iodine atom and a phenylsulfonyl protecting group, makes it a valuable electrophilic building block for cross-coupling reactions and heterocyclic synthesis. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in the development of kinase inhibitors and other biologically active heterocycles.
• Agrochemical Research: Used in the discovery and development of new active ingredients for crop protection products.
• Material Science: Serves as a precursor for functional organic materials, including organic light-emitting diodes (OLEDs) and conductive polymers.
• Cross-Coupling Reactions: The iodine moiety acts as an excellent handle for palladium-catalyzed reactions such as Suzuki, Sonogashira, and Heck couplings to introduce the indole core into more complex systems.
• Chemical Biology Probes: Utilized in the synthesis of labeled compounds and molecular probes for studying biological pathways and protein interactions.
• Academic & Contract Research: Essential reagent for methodological development in organic synthesis and for producing custom-specified compounds in research laboratories.

Basic Information

Product Name	3-Iodo-1-(Phenylsulfonyl)-1H-Indole
CAS No.	80360-14-1
Molecular Formula	C14H10INO2S
Molecular Weight	399.20 g/mol
Synonyms	1H-Indole, 3-iodo-1-(phenylsulfonyl)-; 3-Iodo-1-(benzenesulfonyl)-1H-indole; 1-Benzenesulfonyl-3-iodoindole; N-(Phenylsulfonyl)-3-iodoindole; 3-Iodoindole-1-sulfonic acid phenyl ester; 80360-14-1; 1-(Phenylsulfonyl)-3-iodo-1H-indole
EINECS	Contact for details

Quality Control

Our 3-Iodo-1-(Phenylsulfonyl)-1H-Indole is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical characterization, including HPLC for purity assessment and NMR for structural confirmation, to meet the exacting standards of research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept tightly sealed when not in use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.