Description

n-(n-p-Nitro-Benzyloxycarbonyl)-Formimidoyl-2-Aminoethylthiol is a specialized chemical intermediate featuring a nitrobenzyloxycarbonyl (Npoc) protecting group and a formimidoyl thiol moiety. This compound is critical for synthetic chemists requiring precise, orthogonal protection strategies in complex multi-step organic syntheses. It is primarily utilized in pharmaceutical research and development for the production of novel active pharmaceutical ingredients (APIs) and advanced fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly those requiring selective deprotection under photolytic or mild chemical conditions.
• Peptide Chemistry: Used in the protection of amino groups during solid-phase and solution-phase peptide synthesis, enabling the construction of specific peptide sequences.
• Protecting Group Reagent: Serves as an Npoc-protecting agent for amines, offering a photolabile protecting strategy that is orthogonal to other common protecting groups like Boc and Fmoc.
• Bioconjugation: The reactive thiol and formimidoyl groups facilitate its use in linking molecules, such as in the development of antibody-drug conjugates (ADCs) or diagnostic probes.
• Chemical Biology Research: Employed in the development of activity-based probes and other tools for studying enzyme function and biological pathways.
• Agrochemical Synthesis: Acts as an intermediate in the development of advanced pesticides and herbicides requiring specific, high-purity chiral centers.

Basic Information

Item	Details
Product Name	n-(n-p-Nitro-Benzyloxycarbonyl)-Formimidoyl-2-Aminoethylthiol
CAS No.	80166-50-3
Molecular Formula	C11H11N3O4S
Molecular Weight	281.29 g/mol
Synonyms	2-[[(4-Nitrobenzyloxy)carbonyl]formimidoylamino]ethanethiol; N-[(4-Nitrobenzyloxy)carbonyl]-N'-(2-mercaptoethyl)formamidine; Npoc-protected aminoethylthiol formamidine; 1-(4-Nitrobenzyloxycarbonyl)-2-(2-mercaptoethyl)formamidine; (4-Nitrobenzyl) N-[(2-sulfanylethyl)carbamimidoyl]carbamate; 80166-50-3; Npoc-AET-Fm
EINECS	Contact for details

Quality Control

Our n-(n-p-Nitro-Benzyloxycarbonyl)-Formimidoyl-2-Aminoethylthiol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification results. Our production adheres to cGMP guidelines where applicable, ensuring reliability for critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C) under an inert atmosphere (e.g., nitrogen or argon) due to its sensitivity to oxidation. Keep away from strong oxidizing agents and moisture. For long-term storage, consider refrigeration at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.