Description

1-Hydroxybenzotriazole Hydrate is a versatile and highly effective peptide coupling reagent and catalyst. This compound is critical for suppressing racemization and enhancing coupling efficiency during solid-phase peptide synthesis (SPPS) and solution-phase peptide synthesis. It is an essential raw material for pharmaceutical R&D, fine chemical synthesis, and academic research, where high-purity intermediates are required for producing complex bioactive molecules.

Application

• Primary reagent for peptide coupling in solid-phase and solution-phase synthesis.
• Critical additive in the synthesis of active pharmaceutical ingredients (APIs) and complex organic molecules.
• Used as a catalyst and racemization suppressor in amide bond formation.
• Essential component in bioconjugation and protein labeling techniques.
• Intermediate in the production of specialty fine chemicals and agrochemicals.
• Reagent in academic and industrial research laboratories for method development.

Basic Information

Product Name	1-Hydroxybenzotriazole Hydrate
CAS No.	80029-43-2
Molecular Formula	C₆H₅N₃O·xH₂O
Molecular Weight	135.12 (Anhydrous basis)
Synonyms	HOBt Hydrate; 1-Hydroxy-1H-benzotriazole Hydrate; Hydroxybenzotriazole Monohydrate; 1-Hydroxybenzotriazole; HOBt·H₂O; 1-HOBt; Benzotriazol-1-ol Hydrate; Coupling Reagent HOBt
EINECS	Contact for details

Quality Control

Our 1-Hydroxybenzotriazole Hydrate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity, consistent performance, and compliance with relevant industry standards for fine chemical and pharmaceutical intermediates. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Water Content (KF)	As per hydrate specification
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residue on Ignition	< 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.