Description

Conivaptan is a potent and selective dual arginine vasopressin (AVP) V1a and V2 receptor antagonist. This compound is of significant interest in pharmaceutical research and development, particularly for its therapeutic potential in managing conditions related to fluid and electrolyte imbalance. It is primarily utilized by pharmaceutical manufacturers and advanced research institutions engaged in the development of novel treatments for hyponatremia and congestive heart failure. The product is supplied to meet the stringent quality requirements of the global life sciences industry.

Application

• Pharmaceutical Active Ingredient (API): Serves as the key active component in the formulation of injectable medications for the treatment of euvolemic hyponatremia.
• Clinical Research Material: Used in preclinical and clinical studies to investigate its efficacy and safety profile for various cardiovascular and renal indications.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development, validation, and routine testing of drug products.
• Biochemical Research: Utilized in pharmacological studies to understand the role of vasopressin receptors in physiological and pathophysiological processes.
• Process Development: Acts as a critical intermediate or final compound in the development and optimization of scalable synthetic routes within process chemistry.

Basic Information

Product Name	Conivaptan
CAS No.	8626-94-6
Molecular Formula	C32H26N4O2
Molecular Weight	498.58 g/mol
Synonyms	YM 087; (2S)-4'-[(5R)-7-Chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-1-benzazepin-1-ylcarbonyl]-o-anisamide; N-[4-[(4,5-Dihydro-2-methylimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl]phenyl]-2,4-dimethoxy-5-(1-methylethyl)benzenesulfonamide; Vaprisol (Brand Name); Benzazepine, 7-chloro-5-hydroxy-1-[2-methyl-4-(2-methylbenzoyl)aminobenzoyl]-2,3,4,5-tetrahydro-1H-, (R)-; UNII-713U13E8JU
EINECS	Contact for details

Quality Control

Our Conivaptan is manufactured under strict quality management systems to ensure it meets the high standards required for pharmaceutical applications. Each batch is subjected to comprehensive analytical testing, including identification, purity assay, and impurity profiling using validated methods such as HPLC, IR, and NMR. A Certificate of Analysis (COA) detailing all test results and specifications is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider conditions under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.5%
Related Substances (HPLC)	Total impurities ≤1.5% Any single impurity ≤0.5%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.