Description

Sevelamer Hydrochloride CAS NO 152751-57-0 is a polymeric amine-based phosphate binder used in pharmaceutical formulations. This compound is critical for managing hyperphosphatemia in patients with chronic kidney disease, offering a non-calcium, non-metal alternative. It is primarily required by pharmaceutical manufacturers producing renal care medications and is also utilized in related clinical research and development.

Application

• Active Pharmaceutical Ingredient (API) in oral medications for the treatment of hyperphosphatemia.
• Key component in the formulation of prescription drugs for patients with end-stage renal disease (ESRD) on dialysis.
• Used in the research and development of novel phosphate-binding therapies.
• Reference standard in analytical laboratories for quality control and method validation.
• Investigational material for studying the pharmacokinetics and pharmacodynamics of polymeric binders.
• Potential excipient or functional agent in specialized controlled-release drug delivery systems.

Basic Information

Product Name	Sevelamer Hydrochloride
CAS No.	152751-57-0
Molecular Formula	(C3H7N)n • xHCl
Molecular Weight	Variable (Polymer)
Synonyms	Poly(allylamine hydrochloride) cross-linked; Sevelamer HCl; Poly(allylamine) hydrochloride, crosslinked; RenaGel (trade name); Sevelamerum hydrochloridum; 2-Propen-1-amine, hydrochloride, polymer with 1-chloro-2,3-epoxypropane; Poly(allylamine-co-N,N'-diallyl-1,3-diamino-2-hydroxypropane) hydrochloride
EINECS	Contact for details

Quality Control

Our Sevelamer Hydrochloride is manufactured and tested under strict quality management systems. We ensure compliance with relevant pharmacopeial standards, including USP and EP monographs where applicable. Each batch undergoes rigorous analytical testing for identity, purity, and performance. A comprehensive Certificate of Analysis (COA) is provided with every shipment to guarantee traceability and specification adherence.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic nature, store in a cool, dry place at controlled room temperature (15-25°C). The container must be kept tightly sealed after each use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms
Assay (on dried basis)	NLT 95.0%
Loss on Drying	NMT 10.0%
Residue on Ignition	NMT 1.0%
Heavy Metals	NMT 20 ppm
Phosphate Binding Capacity	Contact for details
Microbiological Control	Meets specified limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.