Description

Fedovapagon is a high-purity, non-peptide small molecule vasopressin receptor agonist with significant pharmacological research interest. Its primary value lies in its selective action on the V2 receptor, making it a critical compound for studying renal water reabsorption and related physiological pathways. This product is essential for pharmaceutical R&D teams, contract research organizations (CROs), and academic institutions focused on developing novel therapeutics for conditions like hyponatremia, polycystic kidney disease, and congestive heart failure.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for analytical method development, validation, and quality control in drug substance and product testing.
• Preclinical Research: Used in in vitro and in vivo studies to investigate the pharmacodynamics and pharmacokinetics of selective V2 receptor agonism.
• Mechanism of Action Studies: A key tool for elucidating the role of vasopressin V2 receptors in water balance, renal function, and cardiovascular regulation.
• Drug Discovery & Development: Acts as a lead compound or pharmacological probe in the discovery of new agents for aquaresis and related disorders.
• Biochemical Assays: Employed in high-throughput screening (HTS) and receptor binding assays to identify and characterize new chemical entities.
• Metabolite Identification: Used in ADME (Absorption, Distribution, Metabolism, Excretion) studies to understand metabolic pathways and identify potential metabolites.

Basic Information

Product Name	Fedovapagon
CAS No.	347887-36-9
Molecular Formula	C₂₀H₂₈N₄O₃
Molecular Weight	372.46 g/mol
Synonyms	Fedovapagon; RWJ-351647; RWJ 351647; 5-Fluoro-2-methyl-N-[4-(5H-pyrrolo[2,1-c][1,4]benzodiazepin-10(11H)-ylcarbonyl)-3-chlorophenyl]benzamide; V2 Receptor Agonist RWJ-351647; YM-087; (R)-Conivaptan Impurity
EINECS	Contact for details

Quality Control

Our Fedovapagon is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant ICH guidelines for stability and analytical procedures, ensuring the material meets the stringent requirements for pharmaceutical reference standards and investigational use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.