Description

p-Methoxytrityl Alcohol is a specialized protecting group reagent widely used in organic synthesis, particularly in oligonucleotide and peptide chemistry. Its core value lies in its selective reactivity, which allows for the temporary protection of hydroxyl groups during complex multi-step synthetic sequences. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and agrochemical industries who require high-purity intermediates for the production of active pharmaceutical ingredients (APIs), nucleic acids, and fine chemicals.

Application

• As a key protecting group reagent for primary hydroxyl groups in nucleoside and nucleotide synthesis.
• Intermediate in the solid-phase synthesis of oligonucleotides for research, diagnostics, and therapeutic applications.
• Building block for the preparation of specialized ligands and catalysts used in asymmetric synthesis.
• Starting material or intermediate in the synthesis of complex natural products and pharmaceutical agents.
• Used in the development of novel materials and polymers requiring protected functional groups.
• Reagent in carbohydrate chemistry for the selective protection of sugar alcohols.

Basic Information

Product Name	p-Methoxytrityl Alcohol
CAS No.	847-83-6
Molecular Formula	C21H20O2
Molecular Weight	304.38 g/mol
Synonyms	4-Methoxytrityl Alcohol; (4-Methoxyphenyl)diphenylmethanol; PMT-OH; p-Methoxytriphenylmethanol; 4-Methoxytriphenylcarbinol; α-(4-Methoxyphenyl)-α-phenylbenzenemethanol; Monomethoxytrityl Alcohol; MMTr-OH
EINECS	212-685-5

Quality Control

Our p-Methoxytrityl Alcohol is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for demanding synthetic applications. We offer material compliant with in-house specifications tailored for research and industrial use. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This material is light-sensitive and should be handled and stored accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	118 - 122 °C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.