Description

Nordihydrocodeine is a semi-synthetic opioid analgesic derived from codeine. This compound is of significant interest in pharmaceutical research and development for its potential analgesic properties and as a key intermediate in the synthesis of other specialized pharmaceutical agents. It serves the needs of advanced research laboratories, pharmaceutical manufacturers, and fine chemical suppliers engaged in the development of controlled substance APIs and reference standards.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of more complex opioid analgesics and antitussive agents.
• Analgesic Research: Used in preclinical and clinical research to study structure-activity relationships (SAR) within the opioid receptor class.
• Reference Standard: Serves as a high-purity certified reference material (CRM) for analytical testing, method development, and quality control in regulatory laboratories.
• Controlled Substance Studies: Employed in forensic and toxicology laboratories for the development and validation of analytical assays.
• Chemical Synthesis: Utilized in organic synthesis for the preparation of novel derivatives with potential therapeutic applications.

Basic Information

Product Name	Nordihydrocodeine
CAS No.	845-69-2
Molecular Formula	C₁₈H₂₁NO₃
Molecular Weight	299.36 g/mol
Synonyms	N-Demethyldihydrocodeine; 4,5α-Epoxy-3-methoxy-17-methylmorphinan-6-ol; Norhydrocodeine; Dihydro-N-norcodeine; 6-Hydroxydihydronorcodeine; Nor-dihydrocodeine; 17-Nordihydrocodeine
EINECS	Contact for details

Quality Control

Our Nordihydrocodeine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical intermediates and research chemicals. Certificates of Analysis (COA) detailing specifications such as assay (HPLC), related substances, residual solvents, and identification are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.