Description

4-(Trifluoromethyl)Thiophenol is a versatile organosulfur building block characterized by a thiol (-SH) group and a strongly electron-withdrawing trifluoromethyl substituent on the aromatic ring. This unique structure makes it a critical intermediate for introducing lipophilic and metabolically stable motifs into advanced chemical architectures. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science sectors seeking to enhance the properties of their target molecules.

Application

• Pharmaceutical Intermediates: Key building block for synthesizing active pharmaceutical ingredients (APIs), particularly those requiring trifluoromethylated aryl sulfide groups for improved bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the CF3 group can enhance lipophilicity and biological activity.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Polymer & Material Science: Employed as a monomer or modifier to introduce specific functional groups into polymers, affecting their surface properties and stability.
• Organic Synthesis & Research: A valuable reagent for constructing complex sulfur-containing compounds in medicinal chemistry and material research programs.

Basic Information

Product Name	4-(Trifluoromethyl)Thiophenol
CAS No.	825-83-2
Molecular Formula	C7H5F3S
Molecular Weight	178.17 g/mol
Synonyms	alpha,alpha,α-Trifluoro-p-thiocresol; 4-(Trifluoromethyl)benzenethiol; p-(Trifluoromethyl)thiophenol; 4-Trifluoromethylphenyl mercaptan; 4-Mercaptobenzotrifluoride; p-Trifluoromethylthiophenol; 1-Mercapto-4-(trifluoromethyl)benzene; Benzenethiol, 4-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethyl)Thiophenol is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including chromatography (HPLC/GC) and spectroscopic methods (NMR, IR), to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting all critical parameters are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C) under an inert atmosphere (e.g., nitrogen) to minimize oxidation. Keep away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.