Description

2-Chloro-1,3,2-Dioxaphospholane (CAS NO 822-39-9) is a highly reactive cyclic phosphite ester chloride, serving as a critical phosphorylating and capping agent in advanced organic synthesis. Its primary value lies in its ability to introduce phosphate or phosphonate groups under controlled conditions, enabling the synthesis of complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and polymer industries, particularly for modifying nucleosides, synthesizing flame retardants, and creating specialized ligands.

Application

• Pharmaceutical Intermediate: Key reagent in the synthesis of nucleotide analogs, prodrugs, and antiviral/anticancer agents.
• Polymer Chemistry: Used as a monomer or modifying agent for producing flame-retardant polymers and functionalized polyphosphoesters.
• Agrochemical Synthesis: Intermediate in the production of organophosphate-based pesticides and plant growth regulators.
• Ligand & Catalyst Preparation: Building block for synthesizing chiral phosphite and phosphoramidite ligands used in asymmetric catalysis.
• Surface Modification: Agent for introducing phosphate groups onto material surfaces to alter wettability and biocompatibility.
• Chemical Research: Versatile phosphorylating agent in academic and industrial R&D for exploring new synthetic methodologies.

Basic Information

Product Name	2-Chloro-1,3,2-Dioxaphospholane
CAS No.	822-39-9
Molecular Formula	C2H4ClO2P
Molecular Weight	126.48 g/mol
Synonyms	2-Chloro-2-oxo-1,3,2-dioxaphospholane; 2-Chloro-1,3,2-dioxaphospholane 2-oxide; 2-Chloro-2-oxo-1,3,2-dioxaphospholane; Ethylene chlorophosphite; 1,3,2-Dioxaphospholane, 2-chloro-; Phosphorochloridic acid, cyclic ethylene ester; 2-Chloro-1,3,2-dioxaphospholan
EINECS	212-500-5

Quality Control

Every batch of 2-Chloro-1,3,2-Dioxaphospholane is produced and tested under stringent quality management systems. We employ advanced analytical techniques including GC, HPLC, and NMR to ensure high purity and consistency, meeting the exacting standards required for pharmaceutical and fine chemical synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at temperatures between 2°C and 8°C (refrigerated) to maximize stability. Due to its hygroscopic and moisture-sensitive nature, the container must be kept under an inert atmosphere (argon or nitrogen) after opening. Keep away from strong acids and incompatible organic solvents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Impurities (GC)	≤ 1.0% (total)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.