Description

2-Acetylthiophene is a versatile organic building block and a key heterocyclic compound featuring a thiophene ring substituted with an acetyl group. This structure makes it a crucial intermediate for synthesizing a wide range of pharmaceuticals, agrochemicals, and advanced materials. It is particularly valued by R&D chemists and process development scientists in the fine chemical and pharmaceutical industries for constructing complex molecular architectures. The compound, identified by CAS NO 88-15-3, is essential for applications requiring specific electronic or steric properties imparted by the thiophene moiety.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing thiophene-based heterocycles for various therapeutic areas.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and insecticides where the thiophene ring contributes to biological activity.
• Material Science & Organic Electronics: Acts as a building block for conductive polymers, organic semiconductors, and non-linear optical (NLO) materials due to its electron-rich aromatic system.
• Flavor & Fragrance Industry: Employed in the synthesis of certain sulfur-containing aroma compounds, contributing roasted, meaty, or savory notes.
• Chemical Research & Development: A fundamental reagent in organic synthesis for Friedel-Crafts acylation studies, metal-catalyzed cross-coupling reactions, and the development of novel heterocyclic compounds.
• Ligand Synthesis: Used to prepare specialized ligands for catalysis in asymmetric synthesis and transition metal chemistry.

Basic Information

Product Name	2-Acetylthiophene
CAS No.	88-15-3
Molecular Formula	C6H6OS
Molecular Weight	126.18 g/mol
Synonyms	Methyl 2-thienyl ketone; 1-(2-Thienyl)ethanone; 2-Thienyl methyl ketone; 2-Acetylthiophene; 2-Thienyl ketone; 2-Thenoine; 2-Thiophenecarboxaldehyde, methyl-; Ethanone, 1-(2-thienyl)-
EINECS	201-803-3

Quality Control

Our 2-Acetylthiophene is produced under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC/HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, physical properties, and impurity profiles is provided with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials. Recommended storage temperature is 2-8°C for long-term stability, though the product is typically stable at controlled room temperature for shorter periods. Keep container tightly sealed when not in use to minimize exposure to air and moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥98.0% (Standard Grade)
Water Content (KF)	≤0.5%
Refractive Index (n20D)	1.565 - 1.575
Boiling Point	~213-214 °C
Density (20°C)	~1.17 g/cm³

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.