Description

6-Fluoro-1,2,3,4-Tetrahydro-Isoquinoline Hydrochloride is a high-purity, fluorinated isoquinoline derivative salt, serving as a critical pharmaceutical intermediate and building block in advanced organic synthesis. Its value lies in the unique reactivity imparted by the fluorine atom and the tetrahydroisoquinoline scaffold, enabling the construction of complex molecules with potential biological activity. This compound is primarily required by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing new drug candidates, particularly in the areas of central nervous system (CNS) and cardiovascular therapeutics.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs) targeting various disease pathways.
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Fluorinated Compound Synthesis: The fluorine atom makes it a valuable building block for introducing fluorine into target molecules to modulate their metabolic stability, lipophilicity, and bioavailability.
• Agrochemical Development: Potential use as an intermediate in the research and synthesis of new generation pesticides and herbicides.
• Chemical Biology Probes: Can be utilized to develop molecular probes for studying enzyme function and biological mechanisms.
• Academic & Industrial R&D: Serves as a research chemical in universities and corporate labs for exploring new synthetic methodologies and heterocyclic chemistry.

Basic Information

Product Name	6-Fluoro-1,2,3,4-Tetrahydro-Isoquinoline Hydrochloride
CAS No.	799274-08-1
Molecular Formula	C9H11ClFN
Molecular Weight	187.64 g/mol
Synonyms	6-Fluoro-1,2,3,4-tetrahydroisoquinoline HCl; 6-Fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride; 6-Fluoro-1,2,3,4-tetrahydroisoquinoline monohydrochloride; 6-Fluoro-THIQ hydrochloride; 6-F-THIQ HCl; 1,2,3,4-Tetrahydro-6-fluoro-isoquinoline hydrochloride; 6-Fluoro-3,4-dihydro-1H-isoquinoline hydrochloride
EINECS	Contact for details

Quality Control

Our 6-Fluoro-1,2,3,4-Tetrahydro-Isoquinoline Hydrochloride is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring consistency and traceability for demanding pharmaceutical and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.