Description

2H-1,3-Oxazine,Tetrahydro-3,4-Dimethyl-5-[(Trimethylsilyl)Oxy]-,(4R,5R)-Rel-(9Ci) is a high-value, stereochemically defined chiral building block and synthetic intermediate. Its core value lies in its unique oxazine ring structure protected by a trimethylsilyl (TMS) group, which provides stability and reactivity control for advanced organic synthesis. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the construction of complex, biologically active molecules.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) and anti-infective agents.
• Asymmetric Synthesis: Serves as a precursor or auxiliary in catalytic asymmetric reactions to introduce stereogenic centers with high enantiomeric purity.
• Natural Product Synthesis: Used in the total synthesis of complex natural products containing functionalized heterocyclic motifs.
• Agrochemical Research: Intermediate for developing new chiral active ingredients for crop protection with improved efficacy and environmental profiles.
• Organosilicon Chemistry: The TMS-protected hydroxyl group allows for selective deprotection and further functionalization under mild conditions.
• Academic & R&D: A valuable reagent for methodological studies in organic chemistry, exploring new reaction pathways and mechanisms.

Basic Information

Product Name	2H-1,3-Oxazine,Tetrahydro-3,4-Dimethyl-5-[(Trimethylsilyl)Oxy]-,(4R,5R)-Rel-(9Ci)
CAS No.	795312-99-1
Molecular Formula	C11H23NO2Si
Molecular Weight	229.39 g/mol
Synonyms	(4R,5R)-3,4-Dimethyl-5-[(trimethylsilyl)oxy]tetrahydro-2H-1,3-oxazine; rel-(4R,5R)-3,4-Dimethyl-5-(trimethylsilyloxy)tetrahydro-2H-1,3-oxazine; Tetrahydro-3,4-dimethyl-5-[(trimethylsilyl)oxy]-2H-1,3-oxazine, (4R,5R)-rel-; (4R,5R)-rel-3,4-Dimethyl-5-(trimethylsilyloxy)tetrahydro-2H-1,3-oxazine; Chiral TMS-protected oxazine; TMSO-oxazine derivative; 795312-99-1; (4R,5R)-3,4-Dimethyl-5-(trimethylsilyloxy)-3,4,5,6-tetrahydro-2H-1,3-oxazine
EINECS	Contact for details

Quality Control

Our production of this advanced chiral intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and high enantiomeric purity, critical for sensitive synthetic applications. Each lot is characterized using advanced analytical techniques including chiral HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles is provided with every shipment to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases and fluorides.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (4R,5R)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.