Description

2-(1,1-Dioxo-Tetrahydro-1Lambda6-Thiophen-3-Ylamino)-4-Methyl-Pentanoic Acid CAS NO 792893-05-1 is a high-purity, non-proteinogenic amino acid derivative featuring a sulfolane (tetrahydrothiophene-1,1-dioxide) moiety. This compound is of significant interest in advanced pharmaceutical research and development, particularly as a sophisticated building block for novel active pharmaceutical ingredients (APIs) and peptide mimetics. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical sectors seeking to introduce unique steric and electronic properties into molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the synthesis of complex drug candidates, especially those targeting neurological and metabolic disorders.
• Peptidomimetic Research: Used to construct non-natural amino acid residues in peptides to enhance metabolic stability, bioavailability, and receptor binding affinity.
• Chemical Biology Probe Development: Acts as a specialized scaffold for creating tool compounds and probes to study enzyme function and protein-protein interactions.
• Asymmetric Synthesis: Employed as a starting material or auxiliary in catalytic asymmetric reactions due to its defined stereochemistry.
• Ligand and Catalyst Design: Provides a unique sulfone-containing framework for developing novel ligands and organocatalysts.
• High-Purity Reference Standard: Supplied as a certified reference material for analytical method development and quality control in API manufacturing.

Basic Information

Product Name	2-(1,1-Dioxo-Tetrahydro-1Lambda6-Thiophen-3-Ylamino)-4-Methyl-Pentanoic Acid
CAS No.	792893-05-1
Molecular Formula	C10H19NO4S
Molecular Weight	249.33 g/mol
Synonyms	2-[(3-Sulfolanyl)amino]-4-methylpentanoic acid; L-Leucine, 2-[(tetrahydro-1,1-dioxido-3-thienyl)amino]-; 2-[(Tetrahydro-1,1-dioxido-3-thienyl)amino]-4-methylpentanoic acid; 2-(1,1-Dioxotetrahydro-3-thienylamino)-4-methylpentanoic acid; 2-[(1,1-Dioxido-3-thiolanyl)amino]-4-methylpentanoic acid; 2-(3-Sulfolanylamino)-4-methylpentanoic acid; (S)-2-((1,1-Dioxotetrahydrothiophen-3-yl)amino)-4-methylpentanoic acid; 792893-05-1
EINECS	Contact for details

Quality Control

Our 2-(1,1-Dioxo-Tetrahydro-1Lambda6-Thiophen-3-Ylamino)-4-Methyl-Pentanoic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization using techniques including HPLC, NMR, and MS to ensure identity, purity, and chiral integrity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical quality attributes. We support cGMP compliance for advanced pharmaceutical applications, and specifications can be aligned with client-specific pharmacopeial or internal standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.