Description

2-Chloro-5,7-difluorobenzothiazole is a high-purity fluorinated benzothiazole derivative, a crucial building block in advanced organic synthesis. Its value lies in its role as a versatile intermediate for constructing complex heterocyclic systems, particularly in the development of active pharmaceutical ingredients (APIs) and specialty agrochemicals. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries seeking to introduce specific halogenated benzothiazole motifs into their target molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and anti-infective therapies.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides, where the benzothiazole core contributes to biological activity.
• Material Science Precursor: Serves as a building block for organic electronic materials, including ligands for OLEDs and components for conductive polymers.
• Dye and Pigment Manufacturing: Acts as an intermediate in the synthesis of specialized fluorinated dyes and fluorescent markers.
• Cross-Coupling Reactions: The chloro and fluoro substituents make it an excellent substrate for Suzuki, Buchwald-Hartwig, and other palladium-catalyzed cross-coupling reactions.
• Ligand and Catalyst Development: Utilized in the preparation of novel ligands for asymmetric catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	2-Chloro-5,7-difluorobenzothiazole
CAS No.	791594-34-8
Molecular Formula	C7H2ClF2NS
Molecular Weight	205.61 g/mol
Synonyms	2-Chloro-5,7-difluoro-1,3-benzothiazole; 5,7-Difluoro-2-chlorobenzothiazole; Benzothiazole, 2-chloro-5,7-difluoro-; 791594-34-8; 2-Chloro-5,7-difluorobenzo[d]thiazole; 2-Chlor-5,7-difluorbenzothiazol (German); 2-クロロ-5,7-ジフルオロベンゾチアゾール (Japanese)
EINECS	Contact for details

Quality Control

Our 2-Chloro-5,7-difluorobenzothiazole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Purity (by HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.