Description

S-(-)-Warfarin-D5 is a stable isotope-labeled analog of the anticoagulant drug warfarin, specifically deuterated at five positions. This compound is essential for use as an internal standard in quantitative bioanalytical methods, ensuring the highest accuracy and reliability in pharmacokinetic and metabolic studies. It is a critical tool for pharmaceutical R&D laboratories, clinical research organizations, and regulatory testing facilities focused on drug development and therapeutic monitoring.

Application

• Internal Standard for LC-MS/MS Analysis: Primary use as a deuterated internal standard for the precise quantification of warfarin enantiomers in complex biological matrices like plasma, serum, and urine.
• Pharmacokinetic and Bioequivalence Studies: Enables accurate measurement of drug concentration-time profiles to determine absorption, distribution, metabolism, and excretion (ADME) parameters.
• Metabolite Identification and Profiling: Aids in distinguishing drug-derived metabolites from endogenous compounds in mass spectrometry-based metabolite screening.
• Therapeutic Drug Monitoring (TDM): Supports the development and validation of robust clinical assays for monitoring warfarin levels in patient samples to optimize dosage and minimize bleeding risks.
• Drug-Drug Interaction Studies: Used in research investigating how co-administered drugs affect the metabolism and clearance of warfarin.
• Reference Material for Certified Standards: Serves as a high-purity calibrant for the preparation of certified reference materials (CRMs) used in quality control laboratories.

Basic Information

Product Name	S-(-)-Warfarin-D5
CAS No.	791013-22-4
Molecular Formula	C19H11D5ClO4
Molecular Weight	312.75 g/mol (for C19H11D5ClO4)
Synonyms	(S)-Warfarin-d5; (S)-3-(α-Acetonylbenzyl)-4-hydroxycoumarin-d5; (S)-4-Hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one-d5; S-Warfarin-d5; Warfarin D5 (S-enantiomer); (S)-Warfarin (phenyl-d5); Coumadin-d5 (S-enantiomer); Deutorase-d5 (S-enantiomer)
EINECS	Contact for details

Quality Control

Our S-(-)-Warfarin-D5 is manufactured under strict quality systems to ensure exceptional isotopic purity and chemical integrity, suitable for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for isotopic enrichment, chemical purity, and identity confirmation via advanced spectroscopic methods. We support compliance with GLP (Good Laboratory Practice) and GMP (Good Manufacturing Practice) standards for research and regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term stability, consider storage at 2-8°C. Keep the container sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Complies with ICH limits
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.