Description

1-(5-Aminoindolin-1-Yl)-2,2,2-Trifluoroethanone is a high-purity, advanced pharmaceutical intermediate characterized by its unique indoline scaffold and trifluoroacetyl functional group. This compound is of significant commercial importance for its role as a key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex heterocyclic chemistry. It is primarily needed by research institutions, custom synthesis houses, and pharmaceutical manufacturers engaged in the development of new drug candidates.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of complex drug molecules, especially those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Research: Serves as a valuable scaffold for developing new agrochemicals, including herbicides and fungicides, due to its bioactive indoline core.
• Material Science: Used in the research and development of specialty chemicals and advanced materials, such as organic semiconductors or liquid crystals.
• Academic & Contract Research: Employed in academic laboratories and CROs (Contract Research Organizations) for method development, structure-activity relationship (SAR) studies, and novel synthetic route exploration.
• Fluorinated Compound Synthesis: Acts as a versatile reagent for introducing the trifluoroacetyl moiety into target molecules, enhancing their metabolic stability and lipophilicity.

Basic Information

Product Name	1-(5-Aminoindolin-1-Yl)-2,2,2-Trifluoroethanone
CAS No.	790677-27-9
Molecular Formula	C10H9F3N2O
Molecular Weight	230.19 g/mol
Synonyms	2,2,2-Trifluoro-1-(5-amino-2,3-dihydro-1H-indol-1-yl)ethanone; 1-(5-Amino-2,3-dihydro-1H-indol-1-yl)-2,2,2-trifluoroethanone; 2,2,2-Trifluoro-1-(5-aminoindolin-1-yl)ethanone; 5-Amino-1-(2,2,2-trifluoroacetyl)indoline; 790677-27-9; 1H-Indole-1-ethanone, 5-amino-2,3-dihydro-2,2,2-trifluoro-
EINECS	Contact for details

Quality Control

Our 1-(5-Aminoindolin-1-Yl)-2,2,2-Trifluoroethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.