Description

Dl-2-Piperidine-D9-Carboxylic Acid is a high-purity, deuterium-labeled isotopologue of pipecolic acid, a non-proteinogenic amino acid. This compound is of significant value as a stable isotope-labeled internal standard in quantitative mass spectrometry, ensuring superior accuracy and reliability in analytical measurements. It is primarily required by pharmaceutical research and development laboratories, contract research organizations (CROs), and academic institutions engaged in advanced metabolic studies, pharmacokinetic analysis, and biomarker discovery.

Application

• As a stable isotope-labeled internal standard (SIL-IS) for the precise quantification of pipecolic acid and related metabolites in biological matrices via LC-MS/MS and GC-MS.
• In pharmacokinetic (PK) and pharmacodynamic (PD) studies to track drug metabolism and disposition with high specificity.
• For biomarker research and validation in areas such as neurological disorders and inborn errors of metabolism where pipecolic acid levels are clinically relevant.
• Use in deuterium labeling chemistry for the synthesis of more complex labeled compounds for research purposes.
• Application in quality control and method development within analytical laboratories to ensure assay robustness and compliance.

Basic Information

Product Name	Dl-2-Piperidine-D9-Carboxylic Acid
CAS No.	790612-94-1
Molecular Formula	C6D9NO2
Molecular Weight	135.19 g/mol (deuterated form)
Synonyms	DL-Pipecolic Acid-d9; (±)-Pipecolic Acid-d9; Hexahydropyridine-2-carboxylic Acid-d9; 2-Piperidinecarboxylic Acid-d9; Homoproline-d9; Pipecolinic Acid-d9; (RS)-Pipecolic Acid-d9; DL-Homoproline-d9
EINECS	Contact for details

Quality Control

Our Dl-2-Piperidine-D9-Carboxylic Acid is manufactured under strict quality systems to ensure exceptional isotopic and chemical purity, critical for its role as an analytical standard. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing results for isotopic enrichment (D-atom %), chemical purity by HPLC, and identification. We adhere to relevant industry standards for high-purity reference materials to guarantee reliable and reproducible performance in sensitive analytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-atom %)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.