Description

6,7-Difluoro-1,2,3,4-Tetrahydro-Isoquinoline is a high-value fluorinated heterocyclic building block essential for advanced organic synthesis. This compound is particularly significant for its role as a key intermediate in the development of novel pharmaceuticals and agrochemicals, where the introduction of fluorine atoms can dramatically alter biological activity and metabolic stability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A critical scaffold for synthesizing potential drug candidates, especially in central nervous system (CNS) and oncology research.
• Agrochemical Synthesis: Used in the development of new-generation herbicides and pesticides with enhanced efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of advanced organic electronic materials and fluorinated polymers.
• Chemical Biology Probes: Useful for creating fluorinated analogs of bioactive molecules to study metabolic pathways and protein interactions.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for bespoke synthesis projects.

Basic Information

Product Name	6,7-Difluoro-1,2,3,4-Tetrahydro-Isoquinoline
CAS No.	787640-44-2
Molecular Formula	C9H9F2N
Molecular Weight	169.17 g/mol
Synonyms	6,7-Difluoro-1,2,3,4-tetrahydroisoquinoline; 1,2,3,4-Tetrahydro-6,7-difluoro-isoquinoline; 6,7-Difluoro-3,4-dihydro-1H-isoquinoline; 6,7-Difluoro-THIQ; DF-THIQ; 787640-44-2; 6,7-Difluorotetrahydroisoquinoline
EINECS	Contact for details

Quality Control

Our 6,7-Difluoro-1,2,3,4-Tetrahydro-Isoquinoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports applications requiring GMP-grade intermediates and research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.