Description

(1R,4R)-Benzyl 2-Oxa-5-Azabicyclo[2.2.1]Heptane-5-Carboxylate CAS NO 787640-37-3 is a high-purity chiral bicyclic lactam building block of significant interest in advanced organic synthesis. Its rigid, three-dimensional scaffold serves as a key intermediate for constructing complex molecules with precise stereochemistry. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for developing new active ingredients.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and antiviral drug candidates.
• Asymmetric Synthesis: Used as a versatile building block in stereoselective synthesis to introduce the constrained 2-oxa-5-azabicyclo[2.2.1]heptane framework into target molecules.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization to explore new chemical space and improve drug-like properties.
• Agrochemical Development: Serves as a precursor for creating new chiral compounds with potential herbicidal or insecticidal activity.
• Catalyst and Ligand Synthesis: Utilized in the preparation of novel chiral catalysts and ligands for enantioselective transformations.
• Academic & Contract Research: A valuable reagent for academic institutions and CROs (Contract Research Organizations) conducting cutting-edge synthetic methodology research.

Basic Information

Product Name	(1R,4R)-Benzyl 2-Oxa-5-Azabicyclo[2.2.1]Heptane-5-Carboxylate
CAS No.	787640-37-3
Molecular Formula	C13H15NO3
Molecular Weight	233.26 g/mol
Synonyms	(1R,4R)-Benzyl 2-Oxa-5-Azabicyclo[2.2.1]heptane-5-carboxylate; (1R,4R)-5-(Benzyloxycarbonyl)-2-oxa-5-azabicyclo[2.2.1]heptane; (1R,4R)-Cbz-2-Oxa-5-Azabicyclo[2.2.1]heptane; (1R,4R)-5-Carbobenzyloxy-2-oxa-5-azabicyclo[2.2.1]heptane; (1R,4R)-2-Oxa-5-azabicyclo[2.2.1]heptane-5-carboxylic acid benzyl ester; (1R,4R)-5-Cbz-2-Oxa-5-Azabicyclo[2.2.1]heptane; Benzyl (1R,4R)-2-oxa-5-azabicyclo[2.2.1]heptane-5-carboxylate; 787640-37-3
EINECS	Contact for details

Quality Control

Our (1R,4R)-Benzyl 2-Oxa-5-Azabicyclo[2.2.1]Heptane-5-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the high standards required for research and development applications. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.