Description

Olanzapine-Methyl-D3 is a deuterated isotopologue of the active pharmaceutical ingredient Olanzapine, specifically labeled on the methyl group. This compound is an essential internal standard for the precise and accurate quantification of Olanzapine in complex biological matrices using advanced analytical techniques. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and analytical service providers engaged in drug metabolism, pharmacokinetic studies, and bioanalytical method development.

Application

• Internal Standard for LC-MS/MS Analysis: Critical for the quantification of Olanzapine in plasma, serum, and tissue samples during bioanalytical studies.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in mass spectrometry to track the absorption, distribution, metabolism, and excretion (ADME) profile of the parent drug.
• Therapeutic Drug Monitoring (TDM): Enables accurate measurement of Olanzapine concentrations in patient samples to optimize dosing regimens.
• Pharmaceutical Impurity Profiling: Assists in the identification and quantification of potential deuterated impurities or metabolites in drug substance batches.
• Clinical Research: Supports clinical trials by providing reliable data on drug exposure and patient compliance.
• Forensic Toxicology: Applied in confirmatory testing for Olanzapine in forensic casework.

Basic Information

Product Name	Olanzapine-Methyl-D3
CAS No.	786686-79-1
Molecular Formula	C₁₇H₁₇D₃N₄S
Molecular Weight	315.43 g/mol
Synonyms	2-Methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine (methyl-d3); Olanzapine-d3 (methyl labeled); LY 170053-d3; Zyprexa-d3; 2-Methyl-4-(4-methylpiperazin-1-yl)-10H-benzo[b]thieno[2,3-e][1,4]diazepine (methyl-d3); Olanzapine (methyl-d3); Olanzapine-methyl-d3 internal standard.
EINECS	Contact for details

Quality Control

Every batch of Olanzapine-Methyl-D3 is manufactured and controlled under a strict quality management system. We provide comprehensive analytical data to ensure the chemical purity, isotopic enrichment, and structural identity meet the exacting requirements for use as a certified reference material. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting results for assay, isotopic purity (D-enrichment), and related substances by HPLC and NMR.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. Due to its hygroscopic nature, the product should be handled in a dry environment and the container kept sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-enrichment)	≥ 98 atom % D
Chemical Purity (NMR)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.