Description

2H-Quinolizine,Octahydro-4-Methyl-,(4R,9As)-(9Ci) is a high-purity, stereochemically defined advanced pharmaceutical intermediate. This compound matters as a critical chiral building block for the synthesis of complex bioactive molecules, offering precise structural control for research and development. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers focused on developing new therapeutic agents, particularly in alkaloid chemistry and medicinal chemistry programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of novel drug candidates, especially those with quinolizidine or related alkaloid backbones.
• Medicinal Chemistry Research: Used as a scaffold or precursor for structure-activity relationship (SAR) studies and library synthesis in drug discovery.
• Asymmetric Synthesis: Employed in catalytic or stoichiometric asymmetric reactions due to its defined stereochemistry at the 4R and 9As positions.
• Reference Standard: Serves as a high-purity analytical standard for method development and quality control in API manufacturing.
• Fine Chemical Production: Integral to the custom synthesis of specialty chemicals for agrochemical or material science applications requiring specific stereoisomers.

Basic Information

Product Name	2H-Quinolizine,Octahydro-4-Methyl-,(4R,9As)-(9Ci)
CAS No.	786638-03-7
Molecular Formula	C10H19N
Molecular Weight	153.27 g/mol
Synonyms	(4R,9aS)-Octahydro-4-methyl-2H-quinolizine; (4R,9aS)-4-Methyloctahydro-2H-quinolizine; (4R,9aS)-4-Methyl-2H-quinolizine, octahydro-; (4R,9aS)-4-Methylperhydro-2H-quinolizine; (4R,9aS)-4-Methylquinolizidine; 4-Methylquinolizidine (stereospecific); (4R,9aS)-Quinolizidine, octahydro-4-methyl-; (4R,9aS)-4-Methyl-1-azabicyclo[4.4.0]decane
EINECS	Contact for details

Quality Control

Our 2H-Quinolizine,Octahydro-4-Methyl-,(4R,9As)-(9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with exacting standards for advanced intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.