Description

Benz[H]Isoquinolin-6(2H)-One, 1,3,4,4A,5,10B-Hexahydro-2,10-Dimethyl-, (4Ar,10Bs)-Rel- (9Ci) is a high-purity, advanced pharmaceutical intermediate with a complex, stereochemically defined polycyclic structure. This compound is valued for its role as a critical building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research. It is essential for R&D chemists and process development scientists in the pharmaceutical and biotechnology industries seeking to develop new therapeutic agents with high specificity.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, especially those targeting neurological pathways.
• Organic Synthesis Building Block: Used in academic and industrial research laboratories for constructing novel heterocyclic compounds and exploring new chemical spaces.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies in drug discovery programs.
• Process Chemistry Development: Employed in the scale-up and optimization of synthetic routes for potential new chemical entities (NCEs).
• Reference Standard: Used as a high-purity analytical standard for quality control and method development in API manufacturing.

Basic Information

Product Name	Benz[H]Isoquinolin-6(2H)-One, 1,3,4,4A,5,10B-Hexahydro-2,10-Dimethyl-, (4Ar,10Bs)-Rel- (9Ci)
CAS No.	786625-21-6
Molecular Formula	C15H19NO
Molecular Weight	229.32 g/mol
Synonyms	rel-(4aR,10bS)-1,3,4,4a,5,10b-Hexahydro-2,10-dimethylbenzo[h]isoquinolin-6(2H)-one; 1,3,4,4a,5,10b-Hexahydro-2,10-dimethylbenzo[h]isoquinolin-6(2H)-one, rel-(4aR,10bS)-; Benzo[h]isoquinolin-6(2H)-one, 1,3,4,4a,5,10b-hexahydro-2,10-dimethyl-, rel-(4aR,10bS)-; (4aR,10bS)-rel-1,3,4,4a,5,10b-Hexahydro-2,10-dimethylbenzo[h]isoquinolin-6(2H)-one
EINECS	Contact for details

Quality Control

Our Benz[H]Isoquinolin-6(2H)-One intermediate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including chiral HPLC, NMR, and mass spectrometry, to ensure high chemical and isomeric purity critical for pharmaceutical applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for each lot to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC, Area %)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.