Description

n-Boc-2-Indolyldimethylsilanol, 95% is a high-purity, protected indole derivative featuring a tert-butoxycarbonyl (Boc) group and a reactive dimethylsilanol moiety. This compound is a critical advanced pharmaceutical intermediate and a versatile organosilicon building block for complex organic synthesis. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing novel molecular architectures.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of complex drug candidates, particularly those targeting neurological and oncological pathways.
• Organosilicon Chemistry: Serves as a versatile building block for creating silicon-containing heterocycles and functional materials.
• Peptidomimetic Research: Used in the development of peptide analogs and protease inhibitors where the indole-silanol structure mimics natural amino acid side chains.
• Agrochemical Synthesis: Intermediate in the production of novel herbicides and fungicides with enhanced activity.
• Ligand and Catalyst Development: Foundation for creating novel chiral ligands and organocatalysts for asymmetric synthesis.
• Material Science Precursor: Used in the development of silicon-based polymers and hybrid organic-inorganic materials.

Basic Information

Item	Detail
Product Name	n-Boc-2-Indolyldimethylsilanol, 95%
CAS No.	784161-48-4
Molecular Formula	C15H23NO3Si
Molecular Weight	293.44 g/mol
Synonyms	2-[(tert-Butoxycarbonyl)amino]-1H-indol-1-yldimethylsilanol; 1-Dimethylhydroxysilyl-2-[(tert-butoxycarbonyl)amino]indole; tert-Butyl (1-(dimethylhydroxysilyl)-1H-indol-2-yl)carbamate; N-Boc-2-aminoindolyldimethylsilanol; Boc-2-Indole-NH-Dimethylsilanol; 2-(Boc-amino)-1H-indol-1-yldimethylsilanol; 1-(Dimethylhydroxysilyl)-2-[(tert-butoxycarbonyl)amino]-1H-indole
EINECS	Contact for details

Quality Control

Our n-Boc-2-Indolyldimethylsilanol, 95% is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the specified 95% minimum purity. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.