Description

Bromo-Peg3-Acid CAS NO 782475-35-8 is a heterobifunctional polyethylene glycol (PEG) derivative featuring a bromoalkyl group and a carboxylic acid terminus, connected by a triethylene glycol spacer. This versatile linker is critical for creating stable, hydrophilic conjugates in pharmaceutical and biotech research, where precise molecular spacing and functional group compatibility are paramount. It is an essential building block for researchers and manufacturers in the fields of bioconjugation, prodrug development, and advanced materials science.

Application

• Bioconjugation Reagent: Used as a heterobifunctional crosslinker for attaching drugs, peptides, or fluorescent dyes to antibodies, proteins, or nanoparticles.
• ADC (Antibody-Drug Conjugate) Development: Serves as a key component in the synthesis of linker-payload constructs, leveraging the bromo group for alkylation and the acid for further coupling.
• Prodrug Synthesis: Facilitates the creation of water-soluble prodrugs by PEGylating active pharmaceutical ingredients (APIs) to improve pharmacokinetics.
• Polymer and Materials Science: Acts as a functional monomer or initiator for synthesizing functionalized polymers, hydrogels, and surface coatings.
• Chemical Biology Probes: Employed in the design and synthesis of activity-based probes and molecular tools for studying biological processes.
• Diagnostic Reagent Manufacturing: Used in the production of diagnostic assay components, such as labeled antibodies and imaging agents.

Basic Information

Product Name	Bromo-Peg3-Acid
CAS No.	782475-35-8
Molecular Formula	C11H21BrO5
Molecular Weight	313.19 g/mol
Synonyms	3-(2-(2-(3-Bromopropoxy)ethoxy)ethoxy)propanoic acid; 8-Bromo-3,6-dioxaoctanoic acid; Bromo-PEG3-propionic acid; Bromo-triethylene glycol-carboxylic acid; Br-PEG3-COOH; 3-Bromopropyl-PEG2-acetic acid; 2-[2-[2-(3-Bromopropoxy)ethoxy]ethoxy]acetic acid; α-Bromo-ω-carboxy-triethylene glycol
EINECS	Contact for details

Quality Control

Our Bromo-Peg3-Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR for structural confirmation, and titration for functional group quantification, to ensure compliance with exacting R&D and cGMP-grade standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. For long-term storage under inert atmosphere, please contact us for specific recommendations. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.