Description

Cycloprop[B]Indole-1A(1H)-Carboxylic Acid, Octahydro-, (1As,2As,6As,6Bs)- (9Ci) is a complex, stereochemically defined heterocyclic carboxylic acid building block of significant interest in advanced organic synthesis. This compound matters as a key chiral intermediate for constructing intricate molecular architectures, particularly in pharmaceutical research and development. It is primarily needed by medicinal chemists and process development scientists working on novel active pharmaceutical ingredients (APIs), especially within the domains of central nervous system (CNS) and antiviral therapeutics. The compound, with CAS number 781676-26-4, offers a rigid, polycyclic framework that is valuable for probing structure-activity relationships.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral scaffold in the synthesis of novel drug candidates targeting neurological disorders.
• Medicinal Chemistry Research: Used as a building block for constructing complex, three-dimensional molecular libraries for high-throughput screening.
• Process Chemistry Development: Employed in route scouting and optimization for the scalable production of advanced intermediates.
• Asymmetric Synthesis: Utilized as a starting material or intermediate in catalytic asymmetric transformations to introduce multiple stereocenters.
• Chemical Biology Probes: Incorporated into molecular probes to study enzyme function or protein-protein interactions due to its unique polycyclic structure.
• Reference Standard: Supplied as a high-purity compound for analytical method development and validation in quality control laboratories.

Basic Information

Item	Details
Product Name	Cycloprop[B]Indole-1A(1H)-Carboxylic Acid, Octahydro-, (1As,2As,6As,6Bs)- (9Ci)
CAS No.	781676-26-4
Molecular Formula	C11H15NO2
Molecular Weight	193.24 g/mol
Synonyms	(1aS,2aS,6aR,6bS)-Octahydro-1H-cyclopropa[b]indole-1a-carboxylic acid; (1aS,2aS,6aR,6bS)-1a,2,3,5,6,6a,6b,7-Octahydrocyclopropa[b]indole-1a-carboxylic acid; Octahydro-1H-cyclopropa[b]indole-1a-carboxylic acid, (1aS,2aS,6aR,6bS)-; Cyclopropa[b]indole-1a(1H)-carboxylic acid, octahydro-, (1aS,2aS,6aR,6bS)-; 781676-26-4; Chiral cyclopropaindole carboxylic acid.
EINECS	Contact for details

Quality Control

Our Cycloprop[B]Indole-1A(1H)-Carboxylic Acid, Octahydro-, (1As,2As,6As,6Bs)- (9Ci) is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the exacting standards required for pharmaceutical R&D. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support compliance with ICH Q7 guidelines and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound is compatible with strong acids and organic solvents but should be stored separately from strong bases and oxidizing agents. For long-term storage, consider inert atmosphere conditions to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.