Description

1H-Benz[E]Indol-6-Ol,2,3,3A,4,5,9B-Hexahydro-1-Methyl-,(1R,3As,9Br)-Rel-(9Ci) CAS NO 781601-09-0 is a high-purity, stereochemically defined indole derivative of significant interest in advanced organic synthesis. This compound serves as a critical chiral building block for the development of complex molecules, particularly in pharmaceutical research. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing novel active compounds.

Application

This specialized chiral intermediate enables the synthesis of complex molecular architectures. Key application areas include:

• Pharmaceutical Intermediate: Serves as a key precursor in the research and development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and other therapeutic agents.
• Asymmetric Synthesis: Utilized as a chiral scaffold or starting material for constructing enantiomerically pure compounds in medicinal chemistry programs.
• Agrochemical Research: Acts as a building block for developing novel pesticides and herbicides with specific stereochemical requirements.
• Fine Chemical Synthesis: Employed in the custom synthesis of complex, high-value specialty chemicals for various industrial applications.
• Academic & Institutional Research: Used in universities and research institutes for methodological studies in organic synthesis and catalysis.
• Process Chemistry Development: Investigated for scalable synthetic routes in pilot plants and kilo-labs for potential commercial manufacturing.

Basic Information

Product Name	1H-Benz[E]Indol-6-Ol,2,3,3A,4,5,9B-Hexahydro-1-Methyl-,(1R,3As,9Br)-Rel-(9Ci)
CAS No.	781601-09-0
Molecular Formula	C13H17NO
Molecular Weight	203.28 g/mol
Synonyms	(1R,3aS,9bR)-1-Methyl-2,3,3a,4,5,9b-hexahydro-1H-benz[e]indol-6-ol; rel-(1R,3aS,9bR)-1-Methyl-1,2,3,3a,4,5-hexahydro-9bH-benz[e]indol-6-ol; 1-Methyl-1,2,3,3a,4,5-hexahydro-9bH-benz[e]indol-6-ol (rel-(1R,3aS,9bR)-form); Benz[e]indol-6-ol hexahydro derivative; Chiral indole alcohol intermediate; CAS 781601-09-0.
EINECS	Contact for details

Quality Control

Our production of this chiral intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and high chemical purity. Quality is verified through a comprehensive suite of analytical techniques including HPLC, GC, NMR, and chiral analysis. A Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles is provided with each shipment. We support development under cGMP guidelines where required for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% e.e.
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.